A Regional Center is a private or public entity authorized by USCIS to operate within defined geographic regions and within specific industry sectors. There is no specific requirement on how such entity is organized. The regional center might be a corporation, an LLC, a partnership or other organization, so long as it operates within the designated geographic region. Selling a regional center, is comparable to selling a business entity under the state law. USCIS has no law regarding sale of a regional center. But an amendment should be filed with USCIS for the change of ownership.