What happens if a current EB-5 applicant gets married to a U.S. citizen? - - Both are very happy.
On a serious note - - No, you cannot exchange your conditional EB-5 permanent resident status for another permanent resident card based on marriage. However, your U.S. citizen spouse can apply for you and you can terminate your current status concurrently with applying for adjustment of status based upon the I-130 petition by your spouse. You would be without work authorization for about 90 days while your application is processing. Therefore, if you feel comfortable that your application to remove your current condition would be approved, you may wish to adjust on the basis of your EB-5 investment without having your spouse petition. You would still be eligible for U.S. naturalization, if you so choose, after having lived with your spouse for 3 years, as contrasted to the standard requirement to have been a U.S. permanent resident for 5 years.